The effect of two different propofol doses on the prevention of nausea and vomiting in discectomy surgery under spinal anesthesia: A triple-blind randomized clinical trial

Introduction: The occurrence of nausea and vomiting is one of the most common complications after surgery. Considering the preventative effect of Pofol on such PONV, the present study evaluated the effect of two different Propofol doses on the prevention of nausea and vomiting in discectomy surgery. Materials and Methods: The present controlled triple-blind clinical trial was performed on 48 patients that were candidates for discectomy surgery under spinal anesthesia and were randomly allocated into three groups. Two different propofol doses of 0.1 and 0.2 mg/kg were intravenously administered in the Pofol 0.1 and 0.2 groups, respectively, with the third placebo group being used as a control group.  Hemodynamic parameters, the severity of nausea and vomiting, and the incidence of complications were evaluated. Results: The results of the present study revealed that the severity of nausea and vomiting in the control group was still more than that of the two propofol groups (P-value <0.05); however, a significant difference was found between the two Pofol doses in terms of the severity of nausea and vomiting (P = 0.02). Conclusion: According to the results of the present study, a low dose of Pofol 0.1 is effective in reducing nausea and vomiting after surgery, but it is less effective than a 0.2 dose of propofol.